Kevin J Tracey Selected Research

Shock

1/2018	Identification of ethyl pyruvate as a NLRP3 inflammasome inhibitor that preserves mitochondrial integrity.
10/2010	Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia.
6/2010	Vagus nerve stimulation regulates hemostasis in swine.
12/2007	Transcutaneous vagus nerve stimulation reduces serum high mobility group box 1 levels and improves survival in murine sepsis.
1/2007	High mobility group box-1 protein induces the migration and activation of human dendritic cells and acts as an alarmin.
12/2005	Immunologic role of the cholinergic anti-inflammatory pathway and the nicotinic acetylcholine alpha 7 receptor.
9/2005	Suppressor alphabeta T lymphocytes control innate resistance to endotoxic shock.
12/2002	Cholinergic antiinflammatory pathway inhibition of tumor necrosis factor during ischemia reperfusion.
3/2002	Pharmacological stimulation of the cholinergic antiinflammatory pathway.

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Kevin J Tracey Research Topics

Disease

118	Inflammation (Inflammations) 01/2024 - 03/2002
79	Sepsis (Septicemia) 04/2024 - 01/2002
39	Endotoxemia 04/2024 - 01/2002
33	Infections 05/2023 - 09/2002
15	Ischemia 01/2021 - 04/2002
12	Necrosis 12/2023 - 04/2002
10	Arthritis (Polyarthritis) 01/2021 - 12/2002
9	COVID-19 11/2023 - 01/2020
9	Shock 01/2018 - 03/2002
8	Rheumatoid Arthritis 10/2023 - 03/2007
8	Pneumonia (Pneumonitis) 01/2020 - 01/2004
7	Body Weight (Weight, Body) 10/2023 - 02/2005
7	Lung Injury 01/2020 - 04/2003
7	Acute Lung Injury 01/2020 - 01/2002
6	Cytokine Release Syndrome 11/2023 - 09/2020
6	Hemorrhage 01/2023 - 02/2005
6	Neoplasms (Cancer) 11/2021 - 04/2005
6	Autoimmune Diseases (Autoimmune Disease) 01/2021 - 02/2012
6	Hemorrhagic Shock 11/2013 - 09/2002
6	Brain Ischemia (Cerebral Ischemia) 03/2011 - 04/2002
5	Pancreatitis 04/2024 - 05/2006
5	Pain (Aches) 01/2023 - 01/2021
5	Neuroinflammatory Diseases 10/2022 - 03/2011
5	Reperfusion Injury 01/2018 - 12/2002
5	Fever (Fevers) 06/2010 - 12/2003
4	Hypertension (High Blood Pressure) 11/2023 - 11/2017
4	Insulin Resistance 01/2021 - 01/2011
4	Experimental Arthritis 01/2016 - 08/2004
4	Atherosclerosis 05/2011 - 03/2007
4	Anorexia 06/2010 - 05/2002
4	Peritonitis 06/2010 - 05/2003
4	Wounds and Injuries (Trauma) 10/2007 - 06/2002
3	Bacterial Infections (Bacterial Infection) 01/2024 - 06/2002
3	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 11/2023 - 08/2009
3	Edema (Dropsy) 01/2023 - 05/2006
3	Disease Progression 04/2022 - 11/2019
3	Multiple Organ Failure (MODS) 01/2022 - 09/2005
3	Chronic Disease (Chronic Diseases) 01/2022 - 12/2015
3	Septic Shock (Toxic Shock Syndrome) 01/2022 - 01/2004
3	Hyperalgesia 01/2021 - 12/2001
3	Alzheimer Disease (Alzheimer's Disease) 01/2021 - 02/2015
3	Hyperglycemia 01/2019 - 11/2015

Drug/Important Bio-Agent (IBA)

100	HMGB1 Protein (HMG1)IBA 10/2022 - 01/2002
81	CytokinesIBA 04/2024 - 05/2002
38	Proteins (Proteins, Gene)FDA Link 10/2022 - 04/2002
27	EndotoxinsIBA 04/2024 - 03/2002
22	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 11/2020 - 03/2002
18	Cholinergic Agents (Cholinergics)IBA 01/2022 - 03/2002
16	AntibodiesIBA 01/2022 - 01/2002
14	Interleukin-6 (Interleukin 6)IBA 11/2023 - 05/2002
9	Receptor for Advanced Glycation End ProductsIBA 11/2019 - 10/2005
8	LipopolysaccharidesIBA 04/2024 - 09/2005
8	Galantamine (Galanthamine)FDA LinkGeneric 04/2024 - 01/2009
7	Biomarkers (Surrogate Marker)IBA 01/2024 - 07/2009
7	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 04/2022 - 05/2006
6	salicylhydroxamic acid (SHAM)IBA 04/2024 - 03/2002
6	AdipokinesIBA 11/2023 - 01/2011
6	InterleukinsIBA 11/2019 - 01/2006
6	LigandsIBA 01/2018 - 10/2005
5	Interleukin-10 (Interleukin 10)IBA 04/2024 - 02/2005
5	Choline O-Acetyltransferase (Choline Acetyltransferase)IBA 11/2023 - 03/2011
5	Monoclonal AntibodiesIBA 01/2023 - 12/2013
5	Cholinesterase Inhibitors (Anticholinesterases)IBA 01/2021 - 01/2009
5	CaspasesIBA 11/2019 - 04/2003
5	EnzymesIBA 01/2019 - 04/2002
5	Acetylcholine (Acetylcholine Chloride)FDA Link 01/2019 - 11/2004
5	InflammasomesIBA 01/2018 - 10/2010
5	DNA (Deoxyribonucleic Acid)IBA 01/2014 - 01/2004
5	Nicotine FDA Link 01/2007 - 11/2004
4	CeruletideIBA 10/2023 - 05/2006
4	ChemokinesIBA 05/2023 - 07/2009
4	Famotidine (Pepcid)FDA LinkGeneric 04/2022 - 01/2020
4	3-(2,4-dimethoxybenzylidene)anabaseineIBA 01/2020 - 05/2006
4	ethyl pyruvateIBA 01/2018 - 09/2002
4	Insulin (Novolin)FDA Link 07/2017 - 11/2015
4	Messenger RNA (mRNA)IBA 12/2016 - 11/2008
4	Hemoglobins (Hemoglobin)IBA 05/2016 - 06/2002
4	Neutralizing AntibodiesIBA 01/2016 - 12/2002
4	alpha7 Nicotinic Acetylcholine ReceptorIBA 09/2008 - 01/2003
3	procathepsin LIBA 01/2024 - 01/2023
3	CholesterolIBA 11/2023 - 07/2017
3	LeptinIBA 11/2023 - 01/2017
3	Toll-Like Receptor 4IBA 11/2021 - 12/2015
3	DisulfidesIBA 11/2021 - 03/2012
3	LipidsIBA 01/2021 - 02/2004
3	Immunoglobulin G (IgG)IBA 01/2021 - 01/2004
3	Peptides (Polypeptides)IBA 01/2019 - 02/2005
3	Adenosine Triphosphate (ATP)IBA 01/2019 - 09/2010
3	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2018 - 05/2007
3	AcetylcholinesteraseIBA 01/2017 - 01/2009
3	Neurotransmitter Agents (Neurotransmitter)IBA 12/2016 - 11/2008
3	Cholinergic ReceptorsIBA 11/2015 - 04/2007

Therapy/Procedure

28	Therapeutics 01/2024 - 01/2003
19	Vagus Nerve Stimulation 10/2023 - 01/2003
14	Punctures 04/2024 - 11/2005
14	Ligation 04/2024 - 11/2005
5	Resuscitation 07/2022 - 02/2005
5	Critical Care (Surgical Intensive Care) 12/2016 - 01/2004
4	Vagotomy 01/2019 - 03/2002
3	Splenectomy 01/2023 - 07/2006